Fast Five Quiz: HR-Positive/HER2-Negative Breast Cancer

Winston W. Tan, MD; Stefania Morganti, MD


June 28, 2023

Figure 1. Human breast cancer cells growing in culture. The clumps of cancer cells are behaving as they would normally, metastasizing and spreading outward. Magnification: 180×.

According to mortality data collected from the National Center for Health Statistics (NCHS) between 1975 and 2020, the best survival pattern is observed among patients with HR+/HER2- breast cancer, immediately followed by the HR+/HER2+ subtype, and then by the HR-/HER2+ subtype. The HR-/HER2- subtype, also known as triple-negative breast cancer, has the worst survival.

Although breast cancer subtype affects survival, stage at diagnosis may be the most powerful factor in determining survival outcome.

Learn more about breast cancer subtypes.


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