Fast Five Quiz: HR-Positive/HER2-Negative Breast Cancer

Winston W. Tan, MD; Stefania Morganti, MD


June 28, 2023

Evaluation of a breast mass is guided by findings on history, physical examination, imaging, and biopsy. Although all these tests might be appropriate at some point, triple testing comprising clinical breast examination, imaging (eg, mammography, ultrasonography), and needle biopsy is needed to lead to a definitive diagnosis.

HR (ie, estrogen receptor and progesterone receptor) status as well as HER2 status are usually confirmed via immunohistochemistry staining of a biopsy specimen after the presence of tumor is confirmed.

Learn more about breast biopsy.


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