Evaluation of a breast mass is guided by findings on history, physical examination, imaging, and biopsy. Although all of these tests might be appropriate at some point, triple testing consisting of clinical breast examination, imaging (eg, mammography, ultrasonography), and needle biopsy can lead to a definitive diagnosis in nearly all cases. Thus, the next test would be biopsy. Hormone receptor (ie, estrogen receptor and progesterone receptor) status as well as HER2 status are usually confirmed via immunohistochemistry staining of a biopsy specimen if there is evidence of cancer. A palpable mass with no imaging findings should still be biopsied. This can be true in some patients with lobular cancer who have a normal mammogram but a palpable mass.
Learn more about breast biopsy.
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Cite this: Winston W. Tan. Fast Five Quiz: HR-Positive/HER2-Negative Breast Cancer - Medscape - Sep 14, 2021.