About 5%-10% of breast cancers are hereditary, and the most common cause of hereditary breast cancer is a BRCA1/BRCA2 mutation. Women with inherited BRCA1 or BRCA2 mutations have about a 72% or 69% lifetime risk for breast cancer, respectively.
Some women with a BRCA1/BRCA2 mutation opt to have prophylactic double mastectomy. Such surgery can reduce the risk of developing breast cancer by up to 95%. Other options include:
Taking medications, such as tamoxifen and raloxifene, and aromatase inhibitors to lower the risk of developing breast or cancer. However, these agents can have significant side effects, including blood clots, endometrial cancer, and dyslipidemia.
Annual screening with breast MRI and mammography, possibly starting at a younger age.
Clinical breast examinations starting at a younger age and done more frequently
Genetic counseling is mandatory.
Colon and ovarian cancer evaluation is highly recommended.
Learn more about BRCA1/BRCA2 mutations.
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Cite this: Winston W. Tan. Fast Five Quiz: HR-Positive/HER2-Negative Breast Cancer - Medscape - Sep 14, 2021.
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