Depending on the amount of psilocybin-containing mushrooms consumed, alterations in perception usually begin within 30 minutes of ingestion (but can start as long as 2 hours after ingestion) and generally subside after 4-6 hours (but can last as long as 12 hours).
Widely varying central nervous system (CNS) manifestations (eg, euphoria, visual and religious hallucinations, and feeling closer to nature) have been reported. Visual hallucinations may include perceived motion of stationary objects or surfaces. Patients presenting in the emergency department may describe more unpleasant effects, such as fear, agitation, confusion, delirium, psychosis, and schizophrenia-like syndromes.
Symptoms may include nausea and sympathomimetic activity, such as mydriasis and tachycardia. Symptoms in children include hyperpyrexia and seizures.
Mushrooms with psilocybin cause fewer adverse reactions than LSD, although cases of hyperthermia, seizures, and coma have been reported. Misidentification of the mushrooms gathered in the wild and purchased on the street is common, leading to reactions other than what was expected.
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Cite this: Richard H. Sinert. Fast Five Quiz: Psilocybin and Other Hallucinogenic Drugs - Medscape - Sep 07, 2021.