Fast Five Quiz: Psilocybin and Other Hallucinogenic Drugs

Richard H. Sinert, DO

September 07, 2021

The onset of psychological effects occurs approximately 30-60 minutes after ingestion of LSD, and they last for approximately 12 hours. Effect peaks at approximately 5 hours. The psychological effects vary both with the individual taking the drug and the physical environment surrounding the user.

Such manifestations as tachycardia, hypothermia, piloerection, hypertension, pupillary dilation, tremor, hypoglycemia, and hyperpyrexia can occur within minutes after oral administration of 0.5-2 µg/kg.

LSD has been found to trigger serotonin syndrome in patients already using precipitating drug combinations (serotonin precursors or agonists, serotonin-release stimulators, SSRIs, nonselective serotonin reuptake inhibitors, nonspecific inhibitors of 5-HT metabolism). Moreover, patients taking SSRIs or lithium have greater potential for LSD-related complications, such as seizures and flashbacks.

1 2 3 4 5 6

Next Section

Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.

Cite this: Richard H. Sinert. Fast Five Quiz: Psilocybin and Other Hallucinogenic Drugs - Medscape - Sep 07, 2021.

Comments

Commenting is limited to medical professionals. To comment please Log-in.

Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.