According to IDSA guidelines, when MRSA is suspected or confirmed in patients with impetigo, doxycycline, clindamycin, or sulfamethoxazole-trimethoprim is recommended.
According to 2021 UK guidelines, antibiotics should not be routinely used in patients with abscesses caused by MRSA that are drained and are < 5 cm in diameter, and where no systemic response and/or immunodeficiency is present. The guidelines also state that rifampicin, fusidic acid, or a quinolone should not be used as a single oral agent in patients with an MRSA bone infection; they should be used in combination with other agents to which the isolate is susceptible.
According to American Heart Association guidelines, prosthetic valve endocarditis secondary to MRSA should be treated with intravenous vancomycin and rifampin for 6 weeks; gentamicin should be concurrently administered over the first 2 weeks of therapy. However, no evidence suggests that combining rifampin or gentamicin with vancomycin or daptomycin is beneficial in patients with native valve endocarditis.
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Cite this: Michael Stuart Bronze. Fast Five Quiz: Staphylococcal Infections - Medscape - Sep 08, 2021.