Compared with those with nonrefractory disease, patients with refractory MG have demonstrated both increased incidence of thymoma and history of thymectomy. Suh and colleagues found that patients with refractory MG were significantly younger at onset than those with nonrefractory disease. These investigators also highlighted the fact that patients with refractory MG are significantly more likely to be women.
In general, MuSK-positive disease status, which shows a strong female predominance, is more difficult to treat than other disease subtypes. Studies conducted by both Suh and colleagues and Baggi and colleagues have demonstrated that MG associated with anti-MuSK antibodies is often more severe and resistant to treatment, and it presents with more aggressive and persistent symptoms (ie, bulbar and respiratory vs ocular).
Learn more about the pathophysiology of MG.
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Cite this: Raghav Govindarajan. Fast Five Quiz: Refractory Myasthenia Gravis - Medscape - Oct 13, 2021.