Fast Five Quiz: Pathophysiology of Myasthenia Gravis

Raghav Govindarajan, MD

Disclosures

October 08, 2021

Patients with MG may have a similar constellation of symptoms regardless of the underlying subtype of disease; however, the immunopathology of each subtype is distinct. Therefore, the disease subtype cannot be determined based on clinical factors alone.

In 40%-50% of patients with ocular MG, autoantibodies are not detected, though this fact does not mean they are not present or causal in disease development. Autoantibodies are likely present even in patients with MG without detectable serum antibodies to either AChR, MuSK, or LRP4, and some patients diagnosed with seronegative MG later show detectable autoantibodies.

Learn more about the pathophysiology of MG.

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