Fast Five Quiz: Pathophysiology of Myasthenia Gravis

Raghav Govindarajan, MD


October 08, 2021

One of the most critical distinctions between the immunopathology of MuSK and AChR MG is the role of the thymus. The thymus is a source for B cells specific for AChR; however, abnormal thymus histopathologic findings are not observed in patients with MuSK MG.

AChR MG can be further divided into subtypes based on age of disease onset and sex. Patients who develop the disease before the age of 40-50 via early-onset MG are often women. Patients who develop the disease after the age of 40-50 are diagnosed with late-onset MG and are more often men. In addition, patients with early-onset MG generally show obvious morphologic changes of the thymus, primarily follicular hyperplasia. About 70% of these patients have germinal center–like structures organized by B cells and antibody-secreting cells.

Learn more about the pathophysiology of MG.


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