Fast Five Quiz: COVID-19 Vaccines

Glenn Wortmann, MD


August 02, 2022

Immunosuppressive medications, such as calcineurin inhibitors, mycophenolic acid, and antiproliferative drugs, have been reported to increase the risk for breakthrough infections by reducing the immunogenicity of vaccines and hindering development of an adequate immune response. For example, a study by Chavarot and colleagues showed a weak antibody response to three doses of mRNA vaccine in kidney transplant recipients treated with the immunosuppressant belatacept. Biguanides (such as metformin), statins, and thyroid hormones (such as levothyroxine) do not worsen breakthrough infection risk.

Learn more about SARS-CoV-2 variants and COVID-19 vaccines.


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