Diagnosis of acquired hemophilia can be difficult, both because the condition is rare and because the patient does not have the usual personal or family history of bleeding episodes, such as is seen in congenital hemophilia. Moreover, the clinical signs and symptoms of acquired hemophilia differ from those of hereditary hemophilia. For instance, intra-articular bleeding episodes, which are typical in congenital factor VIII deficiency complicated by the presence of alloantibodies, are unusual in patients with acquired hemophilia. Instead, hemorrhages into the skin, muscles, or soft tissues and mucous membranes occur in most patients. Bleeding episodes are more frequent and severe in patients with acquired hemophilia than in patients with congenital hemophilia.
Among individuals aged 20-40 years, acquired hemophilia is more common among women. In adults older than 85 years, it is more common among men. The vast majority cases of acquired hemophilia occur in older adults. The median age at presentation is 74-78 years. Unlike patients with hereditary hemophilia, patients with acquired hemophilia do not have a personal or family history of bleeding episodes
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Cite this: Emmanuel C. Besa. Fast Five Quiz: Hemophilia - Medscape - Sep 21, 2021.