Suspect hemophilia C in any patient with a prolonged aPTT, especially if the family history suggests a mild to moderate lifelong bleeding disorder that affects both male and female individuals.
Hemophilia C equally affects males and females. Moreover, people of any age group can be affected. Note that normal infants younger than 6 months have low levels of factor XI because of the time required for factor XI to reach normal levels observed in adults. After this is reached, factor XI levels do not change with age.
Physical findings are usually normal except when bleeding occurs. Bruising may occur at unusual sites. The patient may have signs of pallor, fatigue, and tachycardia with excessive bleeding. Hematuria and spontaneous hemarthrosis are rare. In women, menorrhagia is an important finding, and abnormal bleeding after childbirth may also occur.
Read more on the presentation of hemophilia C.
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Cite this: Emmanuel C. Besa. Fast Five Quiz: Hemophilia - Medscape - Sep 21, 2021.