Fast Five Quiz: Sézary Syndrome

Lauren C. Pinter-Brown, MD

Disclosures

November 01, 2021

Sézary syndrome is an aggressive form of cutaneous T-cell lymphoma. This lymphoma occurs when T cells become cancerous; these cancers characteristically affect the skin, causing different types of skin lesions. In Sézary syndrome, the cancerous T cells, called Sézary cells, are present in the blood, skin, and lymph nodes. A distinctive characteristic of Sézary cells is an abnormally shaped nucleus, described as cerebriform.

The Sézary cells can spread to other organs in the body, including the lymph nodes, liver, spleen, and bone marrow. In addition, affected individuals have an increased risk of developing another lymphoma or other type of cancer.

Although Sézary syndrome is sometimes referred to as a variant of mycosis fungoides, these two cancers are generally considered separate conditions. However, Sézary syndrome is sometimes preceded by mycosis fungoides.

What do you know about Sézary syndrome? Test your knowledge with this quick quiz.

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