Fast Five Quiz: Cold Agglutinin Disease

Salman Aljubran, MD


November 18, 2021

Cold agglutinin disease (CAD) is a rare, complement-dependent, classical pathway–mediated immune hemolytic disease, accounting for up to 25% of autoimmune hemolytic anemia. Whereas the incidence of CAD is rare, the disease burden is frequently high. Premature erythrocyte destruction (hemolysis) results from autoantibodies binding to the erythrocyte membrane. Patients frequently experience painful fingers and toes, with purplish discoloration associated with cold exposure. In recent decades, considerable progress has been made in understanding and treating CAD.

How familiar are you with CAD? Test your knowledge with this quick quiz.


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