Fast Five Quiz: Cold Agglutinin Disease

Salman Aljubran, MD


November 18, 2021

Autoimmune hemolytic anemia is categorized as primary or secondary and is subclassified according to autoantibody type. Primary CAD is characterized by a clonal lymphoproliferative disorder, whereas secondary CAD is the result of a systemic disease (usually infection or cancer).

In most cases (90%), the autoantibody in CAD is IgM. In rare cases, it may involve monoclonal IgG, IgA, or lambda light chain restriction. Conversely, warm autoimmune hemolytic anemia predominantly involves IgG.

Learn more about the epidemiology and pathophysiology of CAD.


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