Fast Five Quiz: Cold Agglutinin Disease

Salman Aljubran, MD


November 18, 2021

Figure 1. Acrocyanosis of the hands. Close-up of the hands of a patient affected by acrocyanosis (right) compared with a normal hand (left). Acrocyanosis is a blue discoloration of the hands and feet due to inadequate blood circulation. This is typically in response to cold temperatures, causing the microcirculation in the fingers and toes to go into spasm.

Hemoglobinuria (the passage of dark urine that contains hemoglobin) is a rare symptom that is the result of hemolysis. It is seen more often in paroxysmal cold hemoglobinuria; occasionally, it may be reported in patients with CAD after prolonged exposure to cold.

Patients with CAD may have mild, moderate, or severe anemia. Anemia symptoms may include fatigue, pallor, dyspnea, and poor feeding. Patients with chronic disease are more symptomatic during colder months.

Learn more about the presentation of CAD.


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