Chemotherapeutic agents should only be used when appropriate, such as for an associated cancer. The use of chemotherapeutic or immunosuppressive agents in the routine management of idiopathic CAD is not recommended.
Plasmapheresis can effectively but temporarily remove IgM antibody from plasma and reduce its concentration. It is a useful procedure for emergencies and for preparing patients for hypothermic surgical procedures, but it is not first-line therapy. B-cell–directed therapies can be used as first-line therapy for patients with severe disease without major comorbidities.
Learn more about the treatment options for CAD.
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Cite this: Salman Aljubran. Fast Five Quiz: Cold Agglutinin Disease - Medscape - Nov 18, 2021.