Fast Five Quiz: Progression of Follicular Lymphoma

Emmanuel C. Besa, MD


November 10, 2021

Kridel and colleagues demonstrated that transformation and progression in FL are promoted by the disruption of distinct biological processes. Their work characterizes transformed FL as the emergence of clones that become highly dominant after transformation but are undetectable in blood samples obtained before transformation occurred. This suggests that histologic transformation into aggressive FL phenotypes, occurring at a rate of about 2%-3% each year, arises after diagnosis.

However, early progression of FL often stems from moderately prevalent clones that are observed in the initial blood samples, with a significant portion of the clonal architecture remaining intact despite treatment. This suggests that resistant properties are already very much present at FL diagnosis.

Learn more about prognostic factors in FL.


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