Kridel and colleagues demonstrated that gene mutations associated with transformation vs early progression differ in the setting of FL. Genes with recurrent mutations associated with early progression included KMT2C, TP53, BTG1, and MKI67. This group also identified novel associations of gene mutations with transformation, including CCND3, GNA13, S1PR2, and P2RY8. In addition, transformed ML appeared to be molecularly diverse; its ABC subtype was enriched for BCL10, CD79B, and MYD88 mutations. These data further support the hypothesis that progression of FL is caused by the disruption of biological processes that are distinct from transformation of FL.
Learn more about prognostic factors in FL.
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Cite this: Emmanuel C. Besa. Fast Five Quiz: Progression of Follicular Lymphoma - Medscape - Nov 10, 2021.