Fast Five Quiz: Management of Mantle Cell Lymphoma

Elwyn C. Cabebe, MD; Ann S. LaCasce, MD, MMSc


January 26, 2023

Various regimens are available for induction therapy for MCL. Guidelines from the NCCN recommend that patients with stage II bulky or stage III-IV MCL who show a partial response to induction therapy be considered for second-line therapy to achieve a complete response.

ISRT with or without chemoimmunotherapy may be considered for patients with stage I or stage II nonbulky MCL.

For patients with stage II bulky or stage III-IV MCL who are not candidates for stem cell transplant, less aggressive therapy is recommended.

Treatment with a BTK inhibitor is not a recommended first-line option.

Learn more about additional MCL management considerations and recommendations.


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