Fast Five Quiz: Workup for Chronic Lymphocytic Leukemia

Mohammad Muhsin Chisti, MD

Disclosures

November 30, 2021

Figure 1. Blood smear showing CLL.

According to guidelines from the International Workshop on Chronic Lymphocytic Leukemia, the presence of ≥ 5 × 109/L B lymphocytes in the peripheral blood, sustained for ≥ 3 months, is required for a diagnosis of CLL. Immunoglobulin light chain restriction using flow cytometry must be used to confirm the clonality of these B lymphocytes. Leukemia cells found in the blood smear are typically small, mature lymphocytes with a narrow border of cytoplasm, as well as a dense nucleus without discernable nucleoli and partially aggregated chromatin.

Learn more about the workup for CLL.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.

processing....