Fast Five Quiz: Workup for Chronic Lymphocytic Leukemia

Mohammad Muhsin Chisti, MD


November 30, 2021

Figure 1. Blood smear showing CLL.

According to guidelines from the International Workshop on Chronic Lymphocytic Leukemia, the presence of ≥ 5 × 109/L B lymphocytes in the peripheral blood, sustained for ≥ 3 months, is required for a diagnosis of CLL. Immunoglobulin light chain restriction using flow cytometry must be used to confirm the clonality of these B lymphocytes. Leukemia cells found in the blood smear are typically small, mature lymphocytes with a narrow border of cytoplasm, as well as a dense nucleus without discernable nucleoli and partially aggregated chromatin.

Learn more about the workup for CLL.


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