The presence of < 5 × 109/L B lymphocytes in the absence of either lymphadenopathy or organomegaly (as discovered by physical examination or imaging studies), or of disease-related cytopenias or symptoms, is considered diagnostic for MBL. Gumprecht nuclear shadows, or smudge cells, found as cellular debris are further morphologic features frequently associated with CLL.
Learn more about the workup for CLL.
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Cite this: Mohammad Muhsin Chisti. Fast Five Quiz: Workup for Chronic Lymphocytic Leukemia - Medscape - Nov 30, 2021.