Figure 2. Palpating lymph nodes.
Large, atypical cells, cleaved cells, and prolymphocytes are frequently seen on the peripheral smear of patients with CLL and may account for ≤ 55% of peripheral lymphocytes. When this percentage is surpassed, B-lymphocyte PLL is more likely than CLL.
The most valuable test to confirm a diagnosis of CLL is peripheral blood flow cytometry, which verifies the presence of circulating clonal B-lymphocytes expressing CD5, CD19, CD20(dim), CD23, and an absence of FMC-7 staining.
Clinicians may consider obtaining serum quantitative immunoglobulin levels in patients who develop repeated infections because monthly intravenous immunoglobulin administration in patients with low levels of immunoglobulin G (< 500 mg) may be helpful in reducing the frequency of infectious episodes.
Learn more about the workup for CLL.
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Cite this: Mohammad Muhsin Chisti. Fast Five Quiz: Workup for Chronic Lymphocytic Leukemia - Medscape - Nov 30, 2021.
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