The differential diagnosis of CLL includes several other entities. Splenic lymphoma with villous lymphocytes is strongly positive for surface immunoglobulin, and is positive for FMC-7, CD22, CD79b, and DBA-44.
Hairy cell leukemia is moderately positive for surface membrane immunoglobulins of multiple heavy-chain classes, and is usually negative for CD5 and CD21.
The typical phenotype of prolymphocytic leukemia is positive for CD19, CD20, and surface membrane immunoglobulin; one half of cases will be negative for CD5.
Finally, follicular lymphoma is also strongly positive for surface immunoglobulin, positive for FMC-7, CD22, CD10, CD79b, and weak for CD23.
Learn more about considerations in the differential diagnosis of CLL.
Editor's Recommendations
Medscape © 2021 WebMD, LLC
Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.
Cite this: Mohammad Muhsin Chisti. Fast Five Quiz: Workup for Chronic Lymphocytic Leukemia - Medscape - Nov 30, 2021.
Comments