Fast Five Quiz: Workup for Chronic Lymphocytic Leukemia

Mohammad Muhsin Chisti, MD


November 30, 2021

The differential diagnosis of CLL includes several other entities. Splenic lymphoma with villous lymphocytes is strongly positive for surface immunoglobulin, and is positive for FMC-7, CD22, CD79b, and DBA-44.

Hairy cell leukemia is moderately positive for surface membrane immunoglobulins of multiple heavy-chain classes, and is usually negative for CD5 and CD21.

The typical phenotype of prolymphocytic leukemia is positive for CD19, CD20, and surface membrane immunoglobulin; one half of cases will be negative for CD5.

Finally, follicular lymphoma is also strongly positive for surface immunoglobulin, positive for FMC-7, CD22, CD10, CD79b, and weak for CD23.

Learn more about considerations in the differential diagnosis of CLL.

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