According to 2021 ACR guidelines, methotrexate is strongly recommended over hydroxychloroquine or sulfasalazine for DMARD-naive patients with moderate to high disease activity. Oral methotrexate is conditionally recommended over subcutaneous methotrexate for patients initiating MTX. Methotrexate is conditionally recommended over alternative DMARDs for DMARD-naive patients with nonalcoholic fatty liver disease, normal liver enzyme levels and findings on liver function tests, and no evidence of advanced liver fibrosis who have moderate to high disease activity. Initiation of a conventional synthetic DMARD without longer-term (≥ 3 months) glucocorticoids is strongly recommended over initiation of a conventional synthetic DMARD with longer-term glucocorticoids for DMARD-naive patients with moderate to high disease activity.
This Fast Five Quiz was excerpted and adapted from the Medscape Drugs & Diseases article Rheumatoid Arthritis.
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Cite this: Herbert S. Diamond. Fast Five Quiz: Rheumatoid Arthritis Myths vs Facts - Medscape - Oct 25, 2021.