Fast Five Quiz: Weight Loss

Romesh Khardori, MD, PhD; Evelyn S. Marienberg, MD


November 08, 2022

Patients taking anti-obesity medications such as orlistat, phentermine/topiramate, naltrexone-bupropion, liraglutide, and semaglutide have been shown to lose 5%-12% more weight than those following a lifestyle plan alone.

Anti-obesity medications are approved for patients with a BMI ≥ 30 or a BMI ≥ 27 with a comorbidity. Other considerations include patients who are actively engaged in self-care, conscientious of their diet but struggling to make dietary changes, unable to lose or maintain a lower body weight, and who have a desire for improved health.

Most anti-obesity medications are intended for long-term use, as discontinuation may result in re-emergence of increased appetite and weight regain. An exception to this is phentermine, which is approved for short-term use only.

Anti-obesity medications should be used in conjunction with lifestyle modifications.

Learn more about anti-obesity medications.


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