Fast Five Quiz: Diagnosis of Crohn Disease

Jaime Shalkow, MD


January 12, 2022

Factors that influence the course of Crohn disease include age of onset, distribution, disease activity, and phenotype. Data suggest that although the annual rate of hospitalization is highest in the first year after diagnosis, it decreases in the following years.

Increased duration and extent of disease add to the risk for neoplasia in Crohn colitis. On the other hand, shorter duration of disease before operation increases the risk for recurrence after surgery.

According to a recent meta-analysis, the 10-year risk of surgical resection is over 30%. Surgical intervention often results in an ileocolic anastomosis and neoterminal ileum, which is frequently the site of recurrence.

The common indications of subsequent surgery are similar to that of initial surgery: failure of medical treatment, bowel obstruction or perforation, fistulas, and abscesses.

Age at diagnosis and sex do not seem to predict disease activity in ulcerative colitis. However, younger age at diagnosis is a risk factor for a more aggressive course of Crohn disease.

Learn more about the prognosis of Crohn disease.


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