Crohn disease is an idiopathic, inflammatory bowel disease (IBD) that results in aberrant immune response to enteric microbiota throughout the gastrointestinal tract. The prevalence and incidence of IBD is increasing worldwide, with the highest rates in Europe and North America. About 3 million Americans are diagnosed with IBD each year, and the incidence is rising. Ashkenazi Jewish individuals are at higher risk for Crohn disease than any other ethnic group. Crohn disease appears to be diagnosed more frequently in urban areas. Among patients with Crohn disease, the age of onset shows a bimodal distribution. The first, more predominant wave occurs in adolescence and early adulthood, whereas the second occurs between the ages of 60 and 70 years, more often in women.
Crohn disease can affect any part of the gastrointestinal tract. The condition's most common symptom is chronic diarrhea. Abdominal pain in the right lower quadrant of the abdomen that worsens postprandially is another hallmark sign. Over time, chronic inflammation in Crohn disease can lead to intestinal complications like fibrotic strictures, enteric fistulas, and intestinal neoplasia. Other symptoms include fatigue and weight loss.
Can you recognize the signs and symptoms of Crohn disease? Test your knowledge with this quick quiz.
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Cite this: Jaime Shalkow. Fast Five Quiz: Signs and Symptoms of Crohn Disease - Medscape - Jan 12, 2022.