Fast Five Quiz: Signs and Symptoms of Crohn Disease

Jaime Shalkow, MD


January 12, 2022

Endoscopic findings that suggest Crohn disease include mucosal nodularity, edema, ulcerations (both aphthous and linear), friability, and stenosis. Histologically, granulomatous inflammation is observed in some patients, as well as focal cryptitis of the duodenum, focally enhanced gastritis, antral thickening, and duodenal strictures. Endoscopic and histologic findings are critical to note during diagnostic workup because these factors play an important role in prognosis, risk for cancer, and disease management decisions.

Common endoscopic findings of ulcerative colitis include edematous mucosa, erythema, loss of vascular markings, and mucosal friability. Focal inflammation around the appendiceal orifice is observed in most patients with ulcerative colitis. More severe cases of ulcerative colitis may cause erosions, ulcers, and spontaneous bleeding.

Learn more about the intestinal manifestations of Crohn disease.


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