Fast Five Quiz: Signs and Symptoms of Crohn Disease

Jaime Shalkow, MD


January 12, 2022

Primary sclerosing cholangitis is the most common hepatobiliary manifestation of Crohn disease, occurring in 5% of patients. These patients are often asymptomatic but have elevated serum alkaline phosphatase concentrations. Other hepatobiliary disorders, such as nonalcoholic fatty liver disease, are often related to IBD medications rather than to the disease itself.

Extraintestinal manifestations of Crohn disease may fall under the categories of arthropathic (axial and peripheral), dermatologic (pyoderma gangrenosum and erythema nodosum), or ocular (uveitis, scleritis, and episcleritis). Some extraintestinal manifestations are more common in Crohn disease than ulcerative colitis.

Findings that are suggestive of Crohn disease on physical examination include tender and swollen joints, aphthous stomatitis, and erythema nodosum that is usually seen on extensor surface of lower extremities. Complications of Crohn disease can also occur in the form of bone fractures and thromboembolism.

Learn more about the presentation of Crohn disease.

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