Fast Five Quiz: Relapsed/Refractory Multiple Myeloma

Maria-Victoria Mateos, MD; Winston W. Tan, MD, FACP

August 16, 2023

Laboratory findings and clinical features that indicate high-risk relapsed multiple myeloma include:

Adverse cytogenetic abnormalities: hypodiploidy, t(4;14), del (17p), amp(1q21)
High beta-2 microglobulin level (≥ 5.5 mg/L) or low albumin (< 3.5 mg/dL)
Extramedullary disease
High lactate dehydrogenase level
Circulating plasma cells
Aggressive clinical features (ie, rapid onset of clinical symptoms; extensive disease at relapse based on workup findings; and disease-associated organ dysfunction at relapse including renal failure, hypercalcemia, or bone event)

Short duration of response and progression while on therapy are also associated with adverse outcomes in multiple myeloma.

Learn more about the prognosis of multiple myeloma.

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Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.

Cite this: Maria-Victoria Mateos, Winston W. Tan. Fast Five Quiz: Relapsed/Refractory Multiple Myeloma - Medscape - Aug 16, 2023.

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