Fast Five Quiz: Relapsed/Refractory Multiple Myeloma

Maria-Victoria Mateos, MD; Winston W. Tan, MD, FACP


August 16, 2023

Laboratory findings and clinical features that indicate high-risk relapsed multiple myeloma include:

  • Adverse cytogenetic abnormalities: hypodiploidy, t(4;14), del (17p), amp(1q21)

  • High beta-2 microglobulin level (≥ 5.5 mg/L) or low albumin (< 3.5 mg/dL)

  • Extramedullary disease

  • High lactate dehydrogenase level

  • Circulating plasma cells

  • Aggressive clinical features (ie, rapid onset of clinical symptoms; extensive disease at relapse based on workup findings; and disease-associated organ dysfunction at relapse including renal failure, hypercalcemia, or bone event)

Short duration of response and progression while on therapy are also associated with adverse outcomes in multiple myeloma.

Learn more about the prognosis of multiple myeloma.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.