Treatment for relapsed multiple myeloma is indicated when patients develop either symptomatic relapse, a rapidly rising paraprotein level, or extramedullary disease. In other cases, a rapidly increasing monoclonal peak (ie, doubling in 3 months or less) would suggest that treatment should be initiated. Patients experiencing biological relapse alone do not always need to be treated immediately.
In the case of asymptomatic biochemical relapse and a slow rise in the paraprotein level, it may be appropriate to restage the patient's disease and take a rigorous wait-and-watch approach, following up at least every 3 months.
Learn more about treatment of multiple myeloma.
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Cite this: Maria-Victoria Mateos. Fast Five Quiz: Relapsed/Refractory Multiple Myeloma - Medscape - Jan 11, 2022.