Fast Five Quiz: Signs and Symptoms of Parkinson's Disease

Rajesh Pahwa, MD


January 13, 2022

Figure 1. Illustration of the brain depicting the neurologic disorder of Parkinson's disease.

Parkinson's disease has four hallmark signs. To make the clinical diagnosis, a patient must demonstrate two of these three symptoms: resting tremor, rigidity, or bradykinesia. The fourth hallmark sign — postural instability — manifests late in the disease course, usually after at least 8 years. To confirm diagnosis, a patient must both demonstrate these core features and respond to dopaminergic therapy. Presenting symptoms can be heterogeneous, thus informing a patient's classification into motor subtypes: tremor dominant, postural instability and gait difficulty, or indeterminate.

Many patients with Parkinson's disease also experience postural and/or kinetic tremor to a certain extent, though resting tremor is the classical presentation of the disease.

Learn more about the presentation of Parkinson's disease.


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