Figure 1. Illustration of the brain depicting the neurologic disorder of Parkinson's disease.
Parkinson's disease has four hallmark signs. To make the clinical diagnosis, a patient must demonstrate two of these three symptoms: resting tremor, rigidity, or bradykinesia. The fourth hallmark sign — postural instability — manifests late in the disease course, usually after at least 8 years. To confirm diagnosis, a patient must both demonstrate these core features and respond to dopaminergic therapy. Presenting symptoms can be heterogeneous, thus informing a patient's classification into motor subtypes: tremor dominant, postural instability and gait difficulty, or indeterminate.
Many patients with Parkinson's disease also experience postural and/or kinetic tremor to a certain extent, though resting tremor is the classical presentation of the disease.
Learn more about the presentation of Parkinson's disease.
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Cite this: Rajesh Pahwa. Fast Five Quiz: Signs and Symptoms of Parkinson's Disease - Medscape - Jan 13, 2022.
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