Parkinson's disease is a clinical diagnosis based mostly on motor features (though nonmotor symptoms should not be overlooked). No laboratory biomarkers can be relied on for this condition, though the measurement of cerebrospinal fluid alpha-synuclein aggregates has offered encouraging preliminary results so far. However, dopamine transporter single-photon emission CT (SPECT) can improve the accuracy of diagnosis. PET and SPECT may also reveal findings that point to Parkinson's disease.
Findings on MRI and CT are usually not valuable in diagnosing Parkinson's disease, and ultrasounds are insufficiently sensitive or specific in the diagnosis of Parkinson's disease and atypical parkinsonism.
Learn more about the workup of Parkinson's disease.
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Cite this: Rajesh Pahwa. Fast Five Quiz: Signs and Symptoms of Parkinson's Disease - Medscape - Jan 13, 2022.