Fast Five Quiz: Overview of Acute Pain Management

Shaheen E. Lakhan, MD, PhD, MS, MEd


January 14, 2022

Gabapentinoids (eg, gabapentin and pregabalin) are anticonvulsants that have been used to treat acute postoperative pain. A recent study found no evidence that preoperative gabapentinoids were associated with reduced risk for prolonged opioid use in patients undergoing a broad range of surgeries. Conversely, other studies in heterogenous patient populations have shown that perioperative gabapentinoid administration was effective in promoting opioid cessation compared with controls; however, in those studies, a clinically significant analgesic effect was not shown.

Despite the mixed evidence, gabapentinoids are currently strongly recommended in ERAS pathways as earlier randomized controlled trials and meta-analyses showed potent perioperative analgesic and opioid-sparing effects in numerous surgical domains, including gynecologic, breast, orthopedic, and spine surgery. However, the optimal dosage, timing, and duration of perioperative gabapentinoid therapy has not been clearly demonstrated.

Learn more about preoperative gabapentinoid use.


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