Fast Five Quiz: Tardive Dyskinesia Causes and Associated Conditions

Christoph U. Correll, MD


August 18, 2023

Anticholinergics are prescribed for conditions including chronic obstructive pulmonary disease, for bladder control issues, and to decrease symptoms associated with Parkinson's disease as well as Parkinsonian symptoms caused by antipsychotic-related dopamine blockade. These agents have been shown to worsen the symptoms of TD and to impair cognitive function. Improvement in TD severity ratings have been observed in up to 60% of patients after withdrawal from anticholinergics. However, clinicians should use caution when deciding to reduce or taper anticholinergics in patients with acute drug-induced movements (eg, parkinsonism or dystonia) or tardive dystonia because these disorders could reemerge or worsen after withdrawal. In patients with TD and parkinsonism, amantadine may be a reasonable and beneficial alternative to anticholinergics.

Learn more about the management of TD.


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