Long-term treatment with dopamine antagonists, including antipsychotics, can cause TD. Although TD can occur with both typical and atypical antipsychotics, atypical antipsychotics seem to carry less risk. Antiemetics, such as metoclopramide, that are potent D2 dopamine receptor antagonists may also cause TD, particularly in older patients. TD has also been linked to use of certain antihistamines and tricyclic antidepressants.
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Cite this: Christoph U. Correll. Skill Checkup: A 55-Year-Old Man With Schizophrenia and New-Onset Involuntary Movements - Medscape - Jan 14, 2022.