Fast Five Quiz: Hyperglycemia Associated With Type 2 Diabetes

Anne L. Peters, MD; Romesh Khardori, MD, PhD


June 28, 2023

Figure 2. Illustration representing the distribution of microvascular complications in a patient with anterior and posterior views.

As shown in the UKPDS study, individuals with type 2 diabetes and chronic hyperglycemia have an increased risk for microvascular complications. Hyperglycemia appears to be the determinant of microvascular and metabolic complications. In contrast, macrovascular disease risk occurs over time. Other factors, such as dyslipidemia and hypertension, play a big role in the development of macrovascular complications. Moreover, the clock for microvascular complications begins ticking well before type 2 diabetes is diagnosed in many cases. In UKPDS, substantial microvascular and macrovascular abnormalities were present in about 50% of patients at the time of type 2 diabetes diagnosis.

Learn more about the impact of hyperglycemia on diabetes-related complications.


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