Fast Five Quiz: Hyperglycemia Associated With Type 2 Diabetes

Anne L. Peters, MD


January 26, 2022

Figure 2. Illustration representing the distribution of microvascular complications in a patient with anterior and posterior views.

As shown in the United Kingdom Prospective Diabetes Study (UKPDS) in people with type 2 diabetes, chronic hyperglycemia is associated with an increased risk for microvascular complications. Hyperglycemia appears to be the determinant of microvascular and metabolic complications, whereas macrovascular disease risk occurred over time. Other factors, such as dyslipidemia and hypertension, play a big role in the development of macrovascular complications. Moreover, the clock for microvascular complications begins ticking well before type 2 diabetes is diagnosed in many cases. In UKPDS, substantial microvascular and macrovascular abnormalities were present in about 50% of patients at the time of type 2 diabetes diagnosis.

Learn more about the impact of hyperglycemia on diabetes-related complications.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.