Fast Five Quiz: Herbal Supplements

Mary L. Windle, PharmD


January 12, 2022

Although more research is needed, St John's wort has shown some efficacy in patients with obsessive-compulsive disorder. Because its mechanism of action is similar to that of selective serotonin reuptake inhibitors, ongoing research is investigating its potential to treat the condition. 

Guidelines from the American College of Physicians describe low-quality evidence from nine clinical trials, which have shown no difference in response or remission when comparing treatment using second-generation antidepressants with St John's wort in patients with major depressive disorder. Evidence was rated as low-quality because the doses of second-generation antidepressants used in the comparative effectiveness studies were lower than usual dosing ranges in comparative studies. St John's wort has been associated with the induction of mania and hypomania, as well as symptoms associated with conditions such as schizophrenia, schizoaffective disorder, and type 1 bipolar disorder.

Learn more clinical information about St John's wort.


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