Fast Five Quiz: Molecular and Biomarker Analysis in Non–Small Cell Lung Cancer (NSCLC)

Daniel S. Schwartz, MD


January 28, 2022

PD-L1 that is expressed on tumor cells can bind to ligands (such as programmed cell death protein 1 [PD-1]); this interaction effectively silences the T-cell response to an NSCLC tumor. Immune checkpoint inhibition is used to block the PD-1/PD-L1 interaction, thereby improving the antitumor effects of endogenous T cells.

ALK rearrangements, ROS1 rearrangements, and MET skipping mutations are all genetic abnormalities that may occur in NSCLC.

Learn more about molecular and biomarker analysis in NSCLC.

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