Fast Five Quiz: The Recurrence Risks for Breast Cancer

Elwyn C. Cabebe, MD


February 08, 2022

Breast-conservation therapy may increase the risk for ipsilateral breast recurrence or contralateral breast cancer in patients with invasive breast cancer who have a known or suspected genetic predisposition to breast cancer. Genes that have been established to confer high susceptibility to breast cancer include pathogenic variants in BRCA1 and BRCA2. Patients with inherited high-risk genetic traits, those with a compelling family history of breast and/or ovarian cancer, or, in some cases, a personal history of receiving thoracic radiation before the age of 30 years, may be considered for prophylactic bilateral mastectomy to reduce their risk.

A discussion of risks and benefits, as well as the use of risk-reduction interventions, such as an aromatase inhibitor, should be considered for women who are positive for a BRCA pathogenic variant.

Learn more about reducing recurrence of breast cancer in patients who are high-risk.


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