The prevalence of iron deficiency in patients with HFpEF is approximately 50%, similar to that in patients with HFrEF, and contributes to worse functional outcomes, although without an impact on hospitalization and mortality.
Nevertheless, the prevalence of iron deficiency in patients with HFpEF, and its impact on functional outcomes, should alert the clinician to the importance of testing for iron deficiency in these patients. The FAIR-HF study is examining whether treatment of iron deficiency in patients with HFpEF can improve functional outcomes. Whether anemia or iron deficiency is the key driver of worsening symptoms and prognosis in patients with HF or whether each is important to the process is currently not known.
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Cite this: Marco Guazzi. Skill Checkup: A 69‐Year‐Old Woman With Acutely Worsening Heart Failure - Medscape - Mar 21, 2022.