According to published consensus recommendations from the 23-member US ME/CFS Clinician Coalition, diagnosis of ME/CFS requires a substantial reduction or impairment in the ability to engage in pre-illness levels of activities that persists for more than 6 months, is accompanied by fatigue (often profound) that is of new or definite onset (not lifelong), is not the result of ongoing exertion, and is not alleviated by rest. It also requires postexertional malaise and unrefreshing sleep, as well as cognitive impairment, orthostatic intolerance, or both.
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Cite this: Michael Stuart Bronze. Fast Five Quiz: Chronic Fatigue Syndrome (Myalgic Encephalomyelitis) - Medscape - Jan 01, 2022.