Fast Five Quiz: Chronic Fatigue Syndrome (Myalgic Encephalomyelitis)

Michael Stuart Bronze, MD


January 01, 2022

Although sleep hygiene practices are a part of treatment, they may be marginally effective in most patients with ME/CFS and need to be tailored for those who are severely ill and those with orthostatic intolerance. Other nonpharmacologic options include meditation and relaxation exercises, ear plugs and eye masks, light therapy, and blue light filters.

Recommended pharmacologic therapies in the 2021 consensus recommendations include:

  • Trazodone

  • Low-dose tricyclic antidepressants (eg, amitriptyline, doxepin)

  • Mirtazapine

  • Antiepileptics (eg, gabapentin, pregabalin)

  • Clonazepam

  • Cyclobenzaprine

  • Zolpidem

  • Eszopiclone

  • Tizanidine

  • Suvorexant

  • Topiramate

  • Hydroxyzine

  • Alpha-blockers (eg, clonidine, guanfacine, prazosin)

  • Diphenhydramine

Read more about medications used for sleep.

This Fast Five Quiz was excerpted and adapted from the Medscape Drugs & Diseases article Chronic Fatigue Syndrome (Myalgic Encephalomyelitis).

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