Although sleep hygiene practices are a part of treatment, they may be marginally effective in most patients with ME/CFS and need to be tailored for those who are severely ill and those with orthostatic intolerance. Other nonpharmacologic options include meditation and relaxation exercises, ear plugs and eye masks, light therapy, and blue light filters.
Recommended pharmacologic therapies in the 2021 consensus recommendations include:
Trazodone
Low-dose tricyclic antidepressants (eg, amitriptyline, doxepin)
Mirtazapine
Antiepileptics (eg, gabapentin, pregabalin)
Clonazepam
Cyclobenzaprine
Zolpidem
Eszopiclone
Tizanidine
Suvorexant
Topiramate
Hydroxyzine
Alpha-blockers (eg, clonidine, guanfacine, prazosin)
Diphenhydramine
Read more about medications used for sleep.
This Fast Five Quiz was excerpted and adapted from the Medscape Drugs & Diseases article Chronic Fatigue Syndrome (Myalgic Encephalomyelitis).
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Cite this: Michael Stuart Bronze. Fast Five Quiz: Chronic Fatigue Syndrome (Myalgic Encephalomyelitis) - Medscape - Jan 01, 2022.