An umbrella review of 28 meta-analyses found that coffee consumption significantly limited rates of endometrial cancer and was characterized by a dose-response relationship. More moderate inverse associations have also been reported between coffee consumption and the risk of developing estrogen receptor–negative and postmenopausal breast cancer, melanoma, basal cell carcinoma, cancer of the oral cavity and pharynx, colorectal cancer, and both lethal and localized prostate cancer.
An Italian study found that consumption of more than four cups of coffee per day increased risk for lymphoma, particularly for the follicular subtype. Older studies found an association between coffee drinking and increased risk for bladder cancer. A Japanese study found no significant association between coffee consumption and the risk for acute myeloid leukemia.
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Cite this: Yasmine S. Ali, Helmi L. Lutsep, Romesh Khardori, et. al. Fast Five Quiz: Coffee Health Effects - Medscape - Jan 07, 2022.