Fast Five Quiz: Management of Helicobacter pylori

Steven F. Moss, MD


January 25, 2022

Figure 1. Enhanced photograph of a benign peptic ulcer in the first part of the duodenum.

According to guidelines from the American College of Gastroenterology (ACG), the identification of mucosa-associated lymphoid tissue (MALT) lymphoma, or marginal zone B-cell lymphoma of MALT type, is a key indication to test for and eradicate H pylori infection.

There is no proven causal association between H pylori infection and GERD; moreover, on a geographical basis, there is a negative association between the prevalence of H pylori infection and the prevalence and severity of GERD. On the basis of the best available evidence, there is no indication to test a patient with typical GERD symptoms for H pylori infection; exceptions would be if the patient also has a history of peptic ulcer disease or dyspeptic symptoms.

The evidence suggesting a relationship between H pylori infection and cirrhosis is weak and insufficient for cirrhosis to be a key indicator for H pylori testing and management.

Although more data are needed, studies to date suggest that there may be a weak inverse association between H pylori infection and allergic or atopic disorders, including eosinophilic esophagitis.

Learn more about practice essentials in the management of H pylori infection.


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