Fast Five Quiz: Management of Helicobacter pylori

Steven F. Moss, MD; Cristian Puerta, MD


October 18, 2023

Figure 1. Enhanced photograph of a benign peptic ulcer in the first part of the duodenum.

The identification of mucosa-associated lymphoid tissue (MALT) lymphoma, or marginal zone B-cell lymphoma of MALT type, is a key indication for testing and eradicating H pylori infection.

Generally, a causal association between H pylori infection and gastroesophageal reflux disease (GERD) isn't common. Moreover, on a geographical basis, data suggest a negative association between the prevalence of H pylori infection and the prevalence and severity of GERD.

The evidence suggesting a relationship between H pylori infection and cirrhosis is generally weak and insufficient for cirrhosis to be a strong key indicator for H pylori testing.

Although more data are needed, studies to date suggest that there may be a weak inverse association between H pylori infection and allergic or atopic disorders, including eosinophilic esophagitis.

Testing for H pylori infection should also be offered to patients with uninvestigated dyspepsia, a history of current or past gastric or duodenal ulcer, a family history of peptic ulcer or gastric cancer, and regular use of nonsteroidal anti-inflammatory drugs.

Learn more about practice essentials in the management of H pylori infection.


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