Fast Five Quiz: Management of Helicobacter pylori

Steven F. Moss, MD

Disclosures

January 25, 2022

Inadequate acid suppression has been associated with H pylori eradication failure. Thus, it is prudent to consider using high-dose and more potent PPIs; PPIs not metabolized by CYP2C19; or potassium-competitive acid blockers, if available, in patients with refractory H pylori infection.

There are some promising data for nonantibiotic adjuncts, such as probiotics, in the treatment of H pylori infection. While the existing data are mostly positive, there are limited data to guide appropriate patient selection, optimal timing, formulation, dosage, and duration, and more rigorous investigation would be valuable.

When used in clarithromycin-based triple therapy, dividing 2-3 mg of amoxicillin into three to four doses daily has been shown to avoid low trough levels and to improve the efficacy of eradication therapy.

Learn more about the management of H pylori infection.

Editor's Recommendations

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.

processing....