Rapid Rx Quiz: Semaglutide

Mary L. Windle, PharmD


January 20, 2022

The STEP 8 trial compared the weight loss efficacy of high-dose semaglutide against liraglutide at its approved dose for obesity (3 mg) in patients with T2D. Patients had a body weight reduction of 15.8% with semaglutide vs 6.4% with liraglutide.

In STEP 2, the higher dose of semaglutide (2.4 mg) achieved slightly better glycemic control, reductions in cardiometabolic risk, and improved physical function relative to the standard dose.

The STEP 1 trial involved patients who were obese or overweight without diabetes. More than 86% in the semaglutide group lost at least 5% of their body weight. In STEP 2, the average body weight reduction with 2.4 mg of semaglutide in patients with diabetes was 9.64%.

The STEP 4 trial found that participants who continued to take semaglutide lost an additional 7.9% of their body weight from weeks 20 to 48. This resulted in a total 17.4% weight loss over the whole trial. Those who switched to placebo after 20 weeks regained an average 6.9%, giving a total weight loss of 5%.

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