Rapid Review Quiz: Insomnia Recent Studies

Stephen Soreff, MD; Helmi L. Lutsep, MD


February 14, 2022

A recent, large cohort analysis found that patients with adult atopic dermatitis (AD) and sleep disorders had higher CRP levels and were at higher risk of developing adverse cardiovascular outcomes and mortality. This suggests that CRP may be a useful prognostic signal in patients with AD and sleep disturbances.

Researchers examined the comorbidity burden of sleep disorders in patients with AD and associated these findings with inflammatory CRP and cardiovascular comorbidities. Adults without AD who presented for general checkup were matched to AD patients by race, age, and sex to serve as controls.

Results showed a higher CRP level in patients with AD who had sleep disturbances (23.3 mg/L vs 20.6 mg/L; P = .02) compared with patients with AD who did not have sleep disturbances, suggesting higher levels of inflammation.

Patients with AD who had sleep disorders were more likely to develop metabolic syndrome (risk ratio [RR], 4.16), atherosclerosis (RR, 2.42), hyperlipidemia (RR, 2.18), obesity (RR, 2.65), peripheral vascular disease (RR, 2.47), stroke (RR, 2.37), type 2 diabetes (RR, 2.45), venous thromboembolism (RR, 2.93), and mortality (HR, 1.24) compared with matched patients who had AD without sleep disorders.

Learn more about AD.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.