A recent, large cohort analysis found that patients with adult atopic dermatitis (AD) and sleep disorders had higher CRP levels and were at higher risk of developing adverse cardiovascular outcomes and mortality. This suggests that CRP may be a useful prognostic signal in patients with AD and sleep disturbances.
Researchers examined the comorbidity burden of sleep disorders in patients with AD and associated these findings with inflammatory CRP and cardiovascular comorbidities. Adults without AD who presented for general checkup were matched to AD patients by race, age, and sex to serve as controls.
Results showed a higher CRP level in patients with AD who had sleep disturbances (23.3 mg/L vs 20.6 mg/L; P = .02) compared with patients with AD who did not have sleep disturbances, suggesting higher levels of inflammation.
Patients with AD who had sleep disorders were more likely to develop metabolic syndrome (risk ratio [RR], 4.16), atherosclerosis (RR, 2.42), hyperlipidemia (RR, 2.18), obesity (RR, 2.65), peripheral vascular disease (RR, 2.47), stroke (RR, 2.37), type 2 diabetes (RR, 2.45), venous thromboembolism (RR, 2.93), and mortality (HR, 1.24) compared with matched patients who had AD without sleep disorders.
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Cite this: Stephen Soreff, Helmi L. Lutsep. Rapid Review Quiz: Insomnia Recent Studies - Medscape - Feb 14, 2022.