Rapid Rx Quiz: Proton Pump Inhibitors (PPIs)

Mary L. Windle, PharmD

Disclosures

February 22, 2022

The umbrella review included 42 systematic reviews with meta-analyses; these were predominantly supported by observational evidence rather than randomized trials. Statistically significant associations with PPI use were reported by the most comprehensive studies for several outcomes, including:

  • Fractures (risk ratio [RR] = 1.20; 95% CI = 1.14-1.28; n = 2,103,800)

  • Kidney disease (RR = 1.61; 95% CI = 1.16-2.22; n = 2,396,640)

  • Infections (odds ratio [OR] = 1.99; 95% CI = 1.73-2.30; n = 356,683)

  • Gastric cancer (OR = 2.50; 95% CI = 1.74-3.85; n = 943,070)

  • Gastrointestinal events (OR = 2.46; 95% CI = 1.42-4.27; n = 40,218)

The research found no associations with neurologic disease or nongastric cancers and found conflicting evidence for cardiovascular outcomes.

Learn more about commonly used PPIs.

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